Caspase-8 prevents sustained activation of NF- B in monocytes undergoing macrophagic differentiation
نویسندگان
چکیده
1Institut National de la Santé et de la Recherche Médicale (INSERM) U517, Dijon, France; 2Institut Fédératif de Recherche (IFR) 100, University of Burgundy, Dijon, France; 3Ecole Pratique des Hautes Etudes (EPHE), Faculty of Medicine, Dijon cedex, France; 4Centre Hospitalier Universitaire, Dijon cedex, France; 5INSERM U567, Institut Cochin, Paris, France; 6Department of Hematology, Cochin Hospital, Paris, France; and the 7Department of Medicine and Biochemistry, Virginia Commonwealth University, Medical College of Virginia, Richmond, VA
منابع مشابه
Caspase-8 prevents sustained activation of NF-kappaB in monocytes undergoing macrophagic differentiation.
Caspases have demonstrated several nonapoptotic functions including a role in the differentiation of specific cell types. Here, we show that caspase-8 is the upstream enzyme in the proteolytic caspase cascade whose activation is required for the differentiation of peripheral-blood monocytes into macrophages. On macrophage colony-stimulating factor (M-CSF) exposure, caspase-8 associates with the...
متن کاملHEMATOPOIESIS Caspase-8 prevents sustained activation of NF- B in monocytes undergoing macrophagic differentiation
1Institut National de la Santé et de la Recherche Médicale (INSERM) U517, Dijon, France; 2Institut Fédératif de Recherche (IFR) 100, University of Burgundy, Dijon, France; 3Ecole Pratique des Hautes Etudes (EPHE), Faculty of Medicine, Dijon cedex, France; 4Centre Hospitalier Universitaire, Dijon cedex, France; 5INSERM U567, Institut Cochin, Paris, France; 6Department of Hematology, Cochin Hospi...
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متن کاملCaspase - 8 prevents sustained activation of NF - κ B in monocytes undergoing
Institut National de la Santé et de la Recherche Médicale (INSERM) U517, Institut Fédératif de Recherche (IFR) 100, University of Burgundy; Ecole Pratique des Hautes Etudes (EPHE), Faculty of Medicine, 7 boulevard Jeanne d’Arc, 21079 Dijon cedex, France; Centre Hospitalier Universitaire, BP1542, 21034 Dijon cedex, France; INSERM U567, Institut Cochin; Department of Hematology, Cochin Hospital, ...
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The differentiation of human peripheral blood monocytes into resident macrophages is driven by colony-stimulating factor-1 (CSF-1), which upon interaction with CSF-1 receptor (CSF-1R) induces within minutes the phosphorylation of its cytoplasmic tyrosine residues and the activation of multiple signaling complexes. Caspase-8 and -3 are activated at day 2 to 3 and contribute to macrophage differe...
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